If your furry friend turns into a drooling, panting mess the moment the car starts moving, you’re not alone – medicine for motion sickness for dogs is one of the most searched-for solutions by pet parents everywhere. Car rides shouldn’t be a nightmare for your pup, and thankfully, there are several effective medications and strategies to help your dog enjoy the journey instead of spending it with their head hanging out the window looking miserable.
Table of Contents
- Understanding Canine Motion Sickness: Why Your Dog Gets Queasy
- Medication Option #1: Dramamine (Dimenhydrinate) – The Classic Choice
- Medication Option #2: Cerenia (Maropitant) – The Prescription Power Player
- Medication Option #3: Bonine (Meclizine) – The Gentler Alternative
- Medication Option #4: Trazodone – When Anxiety Is the Real Culprit
- Medication Option #5: Ondansetron (Zofran) – The Heavy-Duty Nausea Fighter
- Non-Medication Strategies to Complement Your Dog’s Motion Sickness Treatment
- When to See Your Vet About Your Dog’s Motion Sickness
- Creating a Comfortable Travel Environment
- Summary: Your Complete Motion Sickness Action Plan
- Frequently Asked Questions
Understanding Canine Motion Sickness: Why Your Dog Gets Queasy
Before we dive into the remedies, let’s talk about why dogs experience motion sickness in the first place. Unlike humans, dogs don’t have fully developed vestibular systems when they’re puppies, which means their inner ear – responsible for balance – isn’t quite ready for the bumpy road experience. This is especially true for younger dogs, though some adult dogs never quite outgrow the problem.
Motion sickness in dogs manifests as excessive drooling, whining, yawning, vomiting, or that telltale anxious pacing. Some dogs even develop anticipatory anxiety about car rides, making the problem worse over time. The good news? Dog motion sickness medication and other interventions can make a real difference.
Medication Option #1: Dramamine (Dimenhydrinate) – The Classic Choice
Dramamine is probably the most well-known over-the-counter option for treating motion sickness in dogs. This antihistamine works by reducing nausea and dizziness, and it’s been used safely in dogs for decades. The typical dosage is 3-5 mg per pound of body weight, given 30 minutes before travel.
The beauty of Dramamine is its accessibility – you can grab it at any pharmacy without a prescription. However, it does come with some drowsiness as a side effect, which honestly isn’t the worst thing when you’re trying to keep your pup calm during a car ride. Always consult your vet about proper dosing for your specific dog, and when to call the vet about any concerns.
Medication Option #2: Cerenia (Maropitant) – The Prescription Power Player
If over-the-counter options aren’t cutting it, your vet might recommend Cerenia, a prescription medication specifically designed to combat nausea. This is the heavyweight champion of anti-nausea medication for dogs and works differently than antihistamines – it targets the vomiting center in the brain directly.
Cerenia is particularly effective for dogs with severe motion sickness and can be given as an injection or tablet. Many vets prefer this option because it doesn’t cause drowsiness like Dramamine, so your dog stays alert while feeling less queasy. The downside? You’ll need a vet prescription, and it’s pricier than over-the-counter alternatives.
Medication Option #3: Bonine (Meclizine) – The Gentler Alternative
Bonine is another antihistamine option that’s slightly different from Dramamine. It’s often considered gentler and causes less drowsiness, making it ideal if you want your dog to remain alert during travel. The typical dose is 25 mg per dog, regardless of size, which makes dosing super simple.
Many dog owners swear by Bonine because it seems to work well with fewer side effects. It’s available over-the-counter and should be given 30-60 minutes before travel. Just make sure you’re buying the version without additives – some formulations contain ingredients that aren’t safe for dogs.
Medication Option #4: Trazodone – When Anxiety Is the Real Culprit
Sometimes motion sickness in dogs is actually rooted in anxiety rather than a genuine vestibular issue. If your dog’s motion sickness is tied to car anxiety, your vet might prescribe trazodone, a mild sedative that helps dogs relax. When dogs are calm and relaxed, they’re far less likely to experience nausea.

Trazodone works best when given 1-2 hours before travel and helps your dog settle into a peaceful state. It’s prescription-only and requires veterinary guidance, but it can be a game-changer for anxious travelers. Consider scheduling a telehealth vet appointment to discuss whether this might be right for your pup.
Medication Option #5: Ondansetron (Zofran) – The Heavy-Duty Nausea Fighter
For dogs with truly severe motion sickness that doesn’t respond to other treatments, ondansetron is a prescription anti-nausea medication that’s extremely effective. It works by blocking serotonin receptors that trigger the vomiting reflex, making it one of the most potent options available.
Ondansetron is typically reserved for serious cases or dogs undergoing medical procedures that cause nausea, but some vets do prescribe it for chronic motion sickness. It’s more expensive than other options and requires a prescription, but it’s incredibly effective for dogs who need serious intervention.
Non-Medication Strategies to Complement Your Dog’s Motion Sickness Treatment
While medication is important, combining it with other strategies creates the ultimate motion sickness solution. Feed your dog a light meal 2-3 hours before traveling rather than right before – a full stomach makes nausea worse. Keep car rides short initially to help your dog build tolerance, and gradually increase duration as they improve.
Proper ventilation is crucial; crack the windows to equalize air pressure and provide fresh air. Keep your dog secured in a travel crate or with a harness so they feel safe and can’t move around excessively. Some dogs benefit from wearing anxiety wraps or calming supplements like CBD, though always check with your vet first. Consider virtual vet consultations to explore all your options.
When to See Your Vet About Your Dog’s Motion Sickness
If your dog’s motion sickness is severe, persistent, or getting worse over time, it’s definitely time for a professional evaluation. Your vet can rule out underlying health issues like ear infections or neurological problems that might be causing the symptoms. They’ll also help you determine which medication is best suited for your individual dog’s needs and health profile.
Don’t wait for the problem to escalate – early intervention often leads to better long-term outcomes. Your vet can recommend the most appropriate motion sickness treatment for dogs based on your pup’s age, weight, health status, and the severity of their symptoms.
Creating a Comfortable Travel Environment
Beyond medication, the environment matters tremendously. Use window shades to reduce visual stimulation, which can trigger motion sickness in some dogs. Play calming music or use white noise to mask traffic sounds. Keep the car temperature comfortable – overheating makes nausea worse. Some dogs do better facing forward rather than backward, so experiment to see what works for yours.
Positive reinforcement is also crucial. Reward your dog for calm behavior during car rides with praise and treats (given after the ride, not during). Gradually building positive associations with car travel can reduce anxiety-related motion sickness over time. If your dog needs special dietary considerations while on medication, check out appetizing foods for pets on medication.

Summary: Your Complete Motion Sickness Action Plan
Finding the right medicine for motion sickness for dogs is a journey, not a destination. Start with over-the-counter options like Dramamine or Bonine if you want to test the waters, then escalate to prescription options like Cerenia or trazodone if needed. Combine medication with environmental adjustments, positive reinforcement, and gradual exposure to car rides. Most importantly, work closely with your veterinarian to develop a personalized plan that addresses your specific dog’s needs. With the right approach, your dog can transform from a car-sick mess into a happy road trip companion.
Frequently Asked Questions
Can I give my dog Dramamine without a vet’s approval?
While Dramamine is available over-the-counter, it’s always best to consult your vet first. They can confirm that motion sickness is the actual problem, rule out underlying health issues, and provide proper dosing guidance for your dog’s weight and age. What works for one dog might not be ideal for another.
How long does it take for motion sickness medication to work in dogs?
Most medications need 30-60 minutes to take effect, so administer them before you plan to travel. Cerenia can take up to 2 hours for full effectiveness. Always follow your vet’s specific timing recommendations for the medication they prescribe.
Are there natural remedies for dog motion sickness I should try first?
Some natural options like ginger supplements, CBD products, and calming herbs may help, but evidence is limited. Always discuss these with your vet before trying them. Medication combined with behavioral strategies typically produces the best results for moderate to severe cases.
Will my dog outgrow motion sickness?
Many puppies do outgrow motion sickness as their vestibular systems fully develop, usually by 12 months old. However, some adult dogs never outgrow it, and some develop motion sickness later in life due to anxiety or health issues. Consistent exposure to car rides with positive experiences can help.
Is motion sickness in dogs a sign of something serious?
Usually not – it’s often just an inner ear development issue or anxiety. However, sudden onset of motion sickness in an adult dog who previously traveled fine could indicate an ear infection or other health problem. This is worth discussing with your vet.
Can I combine different motion sickness medications?
Never combine medications without explicit veterinary approval. Some combinations can be unsafe. Your vet will recommend one medication or a specific combination if they determine it’s necessary and safe for your dog.







